Hybrid anion exchange hollow fiber membranes (HAEHFMs) based on bromomethylated poly(2,6-dimethyl-1,4-phenylene\r\noxide) (BPPO) are proposed as potential drug carriers for four anionic model drugs, including the sodium salts of benzoate\r\n(NaBS), salicylate (NaSA), meta-amino salicylate (NaMAS), and loxoprofen (NaLS). The results of the static loading and release\r\nexperiments suggest that electrostatic interaction, hydrogen bonding, and hydrophobic interaction are the main interaction\r\npatterns between the membrane and the drugs. And they are directly influenced by the external phase conditions and the drug\r\nphysicochemical characteristics, such as structure, molecular weight, dissociation (pKa), and hydrogen bonding capability. Among\r\nthe four different drugs, NaSA and NaMAS appear to be the most suitable for controlled release by the HAEHFM due to their\r\nexcellent adsorption/release behaviors.
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